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How to Build an External Control Arm for a Wound Care Trial

How to Build an External Control Arm for a Wound Care Trial

Building an external control arm (ECA) for a wound care trial is a data engineering problem disguised as a statistical one. The methodology, propensity matching, IPTW, SMD reporting, is well documented in oncology and cardiology RWE literature. What’s missing is...
CTP Usage by Site of Care: What Real-World Data Reveals

CTP Usage by Site of Care: What Real-World Data Reveals

CTP usage by site of care is not a footnote in real-world evidence, it is a primary axis of variation that national claims averages routinely flatten. A skin substitute that dominates volume in hospital-based wound centers may barely register in SNFs or home health,...
CTP Healing Rates: What the Real-World Data Actually Shows

CTP Healing Rates: What the Real-World Data Actually Shows

A headline CTP healing rate from a pivotal trial and the closure percentage that shows up once the same product circulates through claims and EHR data can differ by 20 to 30 percentage points, sometimes more. That gap is rarely a sign that the product performs...